Anti-TIGIT Therapy
Anti-TIGIT Therapy: Overview of Current Clinical Evidence and Key Ongoing Trials

Released: April 15, 2022

Expiration: April 14, 2023

Ani Balmanoukian
Ani Balmanoukian, MD
Jyoti D. Patel
Jyoti D. Patel, MD

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In this episode, Jyoti D. Patel, MD, and Ani Balmanoukian, MD, discuss several studies investigating agents targeting TIGIT, an emerging immune checkpoint target with promising results in PD-L1-positive NSCLC. The episode includes a review of phase II data on the use of tiragolumab plus atezolizumab in NSCLC, the use of PD-L1 as a marker of response, the potential role of anti-TIGIT therapies in solid tumors, and ongoing trials in lung cancer including SKYSCRAPER-01, SKYSCRAPER-02, SKYSCRAPER-03, and SKYSCRAPER-05.